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【欧盟】评价一种葡聚糖1,4-α-葡萄糖苷酶的宁静性

宣布时候:2021-03-11 阅读量:112
2022年3月9日,欧盟食物宁静局就一种聚糖1,4-α-葡萄苷酶(glucan 1,4-α-glucosidase )的宁静性评价宣布定见。
 
  据领会,这类食物酶是由转基因黑曲霉菌株NZYM-BR出产的,旨在用于出产葡萄糖浆和蒸馏酒精的淀粉加工中。
 
  颠末评价,专家小组以为,在预期的利用前提下,不能解除饮食裸露引发过敏和引发反映的危险,但这类环境产生的能够性很低。按照所供给的数据,小组得出论断,该食物酶在预期的利用前提下不会引发宁静隐患。局部原文报道以下:
 

  The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan glucohydrolase, EC 3.2.1.3) is produced with the genetically modified Aspergillus niger strain NZYM-BR by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in starch processing for the production of glucose syrups and distilled alcohol. Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of glucose syrups and by distillation, dietary exposure estimation was considered not necessary. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,135 mg TOS/kg body weight (bw) per day, the highest dose tested. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched for and two matches were found. The Panel considered that under the intended conditions of use (other than distilled alcohol production) the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.



文章来历:食物火伴网


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